Cultured Human Epidermal Cells Do Not Synthesize HLA-DR
نویسندگان
چکیده
منابع مشابه
Study of HLA-DR synthesis in cultured human keratinocytes.
Within the normal human epidermis only Langerhans and indeterminate cells express HLA-DR. Human keratinocytes (HK), however, may also express HLA-DR in certain disease states characterized by mononuclear cell infiltrates. Previous studies have shown that HK synthesize HLA-DR in response to stimulation by interferon gamma (INF-gamma). The purposes of this study were to define conditions under wh...
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We have investigated normal human corneas for the presence of T6-marker on Langerhans cells. With the exception of one pair of newborn corneas and two pairs of very young infant corneas, all HLA-DR-positive cells in central and peripheral corneal epithelium were T6-negative by double-labeled immunofluorescence. In contrast, epidermal sheets from normal human eyelid skin displayed positive stain...
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The genomic organization and number of human HLA-DRB class II genes differs between haplotypes in the human population. In contrast, both HLA-DQ and -DP class II subregions are conserved. Understanding of the evolutionary relationship and age of HLA-DR haplotypes has been obtained by nucleotide sequence determination and phylogenetic analyses of intron sequences of all known DRB genes from diff...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1982
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12497875